화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.33, No.1, 67-71, January, 2009
Export Citation
클릭 화학에 의한 폴리(벤질에테르)덴드리머의 효율적인 합성
Synthesis of Poly(benzyl ether) Dendrimers by Click Chemistry
이재욱1, 2, †, 이언엽1, 한승철2, 김지현3, 진성호4
  • 1동아대학교 화학과
  • 2동아대학교 의생명과학과
  • 3경원대학교 화학생명공학과
  • 4부산대학교 화학교육학과
Jae Wook Lee1, 2, †, Un Yup Lee1, Seung Choul Han2, Ji Hyeon Kim3, and Sung-Ho Jin4
  • 1Department of Chemistry, Dong-A University, Hadan-2-dong, Busan 604-714, Korea
  • 2Department of Medical Bioscience, Dong-A University, Hadan-2-dong, Busan 604-714, Korea
  • 3Department of Chemical and Bio Engineering, Kyungwon University, Seongnam 461-701, Korea
  • 4Department of Chemistry Education & Center for Plastic Information System, Pusan National University, Busan 609-735, Korea
E-mail:
초록
프레체형태 덴드리머의 합성을 위한 연결 방법이 알카인기와 아지드기 사이의 클릭 화학을 이용하여 개발되었다. 덴드리머의 핵으로 작용할 수 있는 단위체인 4,4′-(3,5-비스(아지도프로필옥시)벤질옥시)비스페닐이 알카인덴드론과 클릭 반응을 통해 덴드리머의 구축을 위해 사용되었다. 즉, 구리촉매 존재하에서 다중(아지드)화합물과 말단 알킨기를 가지는 폴리(벤질에테르)덴드론 사이의 클릭 반응을 통해 덴드리머의 합성 전략이 완성되었다.
The stitching method for the synthesis of Frechet-type dendrimers was elaborated using click chemistry between an alkyne and an azide. The core building block, 4,4′-(3,5-bi(azidopropyloxy) benzyloxy)bisphenyl, was designed to serve as the azide functionalities for dendrimer growth via click reactions with the alkyne-dendrons. The synthetic strategy involved an 1,3-dipolar cycloaddition reaction between an azide and an alkyne-functionalized Frechet-type dendrons in the presence of Cu(I) species which is known as the best example of click chemistry.
Keywords:alkyne;azide;click chemistry;frechet-type dendrimers.
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