Journal of the American Chemical Society, Vol.130, No.3, 833-833, 2008
Copper-catalyzed aerobic oxidative amidation of terminal alkynes: Efficient synthesis of ynamides
A copper-catalyzed method for the preparation of ynamides has been identified that proceeds via aerobic oxidative coupling of terminal alkynes with various nitrogen nucleophiles, including cyclic carbamates, amides and ureas, and N-alkyl-arylsulfonamides and indoles.