Journal of the American Chemical Society, Vol.130, No.12, 3726-3726, 2008
Signal amplification via intramolecular energy transfer using tripodal neutral iridium(III) complexes upon binding to avidin
A neutral tripod system for biotin-avidin assays, which is composed of biotin, Flrpic as an energy acceptor, and mCP as an energy donor, offers remarkable sensitivity over traditional transition metal based protein probes due to the intramolecular energy transfer and increased hydrophobicity associated with the avidin binding site and neutral probe 1.