Journal of the American Chemical Society, Vol.130, No.12, 3728-3728, 2008
Direct asymmetric iodination of aldehydes using an axially chiral bifunctional amino alcohol catalyst
A direct asymmetric iodination reaction of aldehydes with NIS was found to be catalyzed by the novel axially chiral bifunctional amino alcohol (S)-1 d. This method represents the rare example of the catalytic and highly enantioselective synthesis of optically active alpha-iodoaldehydes.