The effects of temperature and pressure on the structure of the trickle-to-pulse flow regime transition in slow-mode cyclic operation in trickle-bed reactors were reported. The relationship between liquid holdup and liquid velocities at the trickle-to-pulse flow transition in cyclic operation, the shock wave behavior as a function of bed depth, as well as the pulsing flow regime properties were investigated for Newtonian (air-water) and non-Newtonian (air-0.25% carboxymethylcellulose (CMC)) liquids. At a given temperature, the breakthrough, plateau and decay times of the shock wave were found to decrease with bed depth. The pulse velocity and pulse frequency for pulsing flow regime both in cyclic operation and in natural pulsing (constant-throughput operation) were observed to increase with temperature. However, increasing the reactor pressure led to increased pulse frequency and decreased pulse velocity. Analysis of the transition liquid holdups for natural pulse flow and cyclic operation revealed that the liquid holdup decreased with temperature and pressure. The transition liquid holdups and superficial liquid pulse velocities in symmetric peak-base cyclic operation surpassed those in constant-throughput operation for given temperature, pressure and gas velocity, giving rise to wider trickle flow regime area in cyclic operation. The behavior of both Newtonian and power-law non-Newtonian fluids was similar regarding the effect of temperature, pressure and gas velocity. (C) 2007 Elsevier Ltd. All rights reserved.