Chemistry Letters, Vol.37, No.1, 94-95, 2008
Photochemical site-specific mutation of 5-methylcytosine to thymine
In this study, we report that the coupling of 5-methylcytosine with 5-carbamoylvinyl-deoxyuridine-mediated photoligation caused the heat-induced transition from 5-methylcytosine to thymine. Deamination of 5-methylcytosine to thymine proceeded via the formation of cyclobutane dimer.