Experimental solubilities of betulin in mixed solvents of chloroform (1)+ methanol (2) were determined at T = (278.2,288.2,293.2,298.2,308.2 and 313.2) K. The solubilities of betulin in mixed solvents of chloroform (1) + methanol (2) increase with increasing of temperature. The curves of solubility versus solvent composition on solute-free basis went through a maximum. Experimental data of solubilities were correlated with a three-parameter equation. In addition, three crystals of betulin obtained in different compositions of chloroform (1) + methanol (2) mixtures were characterized by scanning electron microscope (SEM) and differential scanning calorimetry (DSC). (C) 2008 Elsevier B.V. All rights reserved.