Flory-Huggins interaction parameters determined by inverse gas chromatographic (IGC) technique have been used for the estimation of solubility parameters of nonvolatile branched hydrocarbon solvents. A family of isosteric branched hydrocarbons consists of one apolar stationary phase, 19,24-dioctadecyldotetracontane (C78), and four polar stationary solvents formed by replacing one of the -CH3 groups of C78 by -OH (POH), -CN (PCN), -SH (PSH), -CF3 (MTF), and two other polar solvents formed by replacing four -CH3 groups of C78 with four -CF3 (TTF) and -OCH3 (TMO) are investigated. The three-dimensional Hansen solubility parameters of the solvents have been estimated following the approaches of Voelkel and the method of Huang at five different temperatures. In the three components estimated by Voelkel method, the dispersion component is decreasing rapidly, whereas the polar, and hydrogen bonding components of the solubility parameters are increasing with temperature. In the components of solubility parameter estimated by Huang method, the dispersion and hydrogen bonding components are slowly decreasing with temperature, however, the polar components are almost constant with temperature. The components of solubility parameters for different solvents have been discussed in terms of solvent polarity. (c) 2008 Wiley Periodicals, Inc.