The generalized Flory-dimer (GFD) equation of state (EOS) developed by Hall and coauthors is employed in this study on the vapor-liquid equilibrium (VLE) calculations of polymer solutions. This EOS is applied in real fluid systems where the pure component parameters of the low molecular weight compounds and polymers are regressed using experimental data. Simple mixing rules are employed in this study for binary fluid mixtures of polymers and solvents. It is observed that the GFD EOS yields good VLE calculation results on polymer solutions. The calculated results of the activities and solubilities of solvents in polymer solutions are very satisfactory. The absolute average deviations from the GFD EOS are smaller than those from the SAFT EOS and the Sanchez-Lacombe EOS. The GFD EOS is also compared with other EOS or activity coefficient models on their calculated results of the activity coefficients of solvents at infinite dilution. The GFD EOS again shows better agreement with experimental data than that from other models.