The effect of lithium chloride (LiCl) at salt mole fractions from 0.005 to 0.15 and at saturation on vapor-liquid equilibrium (VLE) of the binary acetone-methanol system has been experimentally investigated at 101.32 kPa using a modified Othmer equilibrium still, in order to elucidate the behavior of this mixture whose existing data are rather contradictory. The salting-out effect of the salt on the VLE of the mixed solvent was explained by the preferential solvation theory. The experimental data were correlated by the electrolytic NRTL model of Mock et al. (1986). The mean absolute deviations of the correlation for gamma and T are 0.018 and 0.74 K, respectively.