Microelectrodes implanted in the brain are increasingly being used to treat neurological disorders. However, robust and reliable chronic application of neural electrodes remains a challenge. Here, we report the use of conducting polymer nanotubes as highly selective neural interfaces for chronic neural recordings. Poly (3,4-ethylenedioxythiophene) nanotubes were formed on the chronic neural microelectrode. The quality of neuronal spike recordings was significantly improved relative to metal electrode sites.