A computational fluid dynamics (CFD) model is proposed, based on ANSYS-CFX tools coupled to optimization models inside the commercial optimization software mode-FRONTIER in order to obtain an optimal design of a high-efficiency impeller, for solids suspension. The analysis of impeller shape performance was carried out using the shear-stress transport (SST) turbulence model with streamline curvature correction. This turbulence model combined the advantages of the kappa-epsilon and kappa-omega models, ensuring a proper relation between turbulent stress and turbulent kinetic energy, allowing ail accurate and robust prediction of the impeller blade flow separation. The multiple frames of reference and the frozen rotor frame change models were used for the rotor/stator interaction inside the mixing vessel. The optimization procedure used seven design variables, two nonlinear constraints and two objective functions. The objective functions chosen (among many other possible options) to evaluate the impeller performance were the maximum solid distribution throughout the vessel (homogeneous suspension) reflected by a low variance between local solid concentration and average solid concentration inside the vessel and the higher pumping effectiveness, which was defined as the quotient of the flow and power numbers. The first objective function searches for impeller configurations able to provide good solid suspension, since it aims to achieve homogeneous suspension. The second objective function aims to reduce power consumption for a high-pumping capacity of the impeller. These criteria were considered enough to characterize the optimized impeller. Results indicated that the optimized impeller presented all increase of the pumping impeller capacity and homogeneous solid suspension with low-power consumption, especially when compared with the PBT 45 degrees impeller. (C) 2009 American Institute of Chemical Engineers AIChE J, 55: 1723-1735, 2009