MAP kinase: It's been longer than fifteen minutes

Sturgill TW

Biochemical and Biophysical Research Communications, Vol.371, No.1, 1-4, 2008

DOI10.1016/j.bbrc.2008.04.002 Export Citation

MAP kinase: It's been longer than fifteen minutes

The review highlights evidence for different functions in the cell cycle of the two MAP kinase kinases, MEK1 and MEK2, and the two MAP kinases, ERK1 and ERK2. Functional differences may explain why instances of cell cycle arrest can be MEK1 or MEK2 dependent. (c) 2008 Elsevier Inc. All rights reserved.

Keywords:MAP kinase;cell cycle;MEK1;MEK2;ERK1;ERK2