The collection of gene deletion mutants of Saccharomyces cerevisiae Was used to screen for novel genes required for UV-induced mutagenesis. We found the SBF transcription factor (Swi4/Swi6 protein complex) to be required for wild-type levels of UV mutability in forward and reverse Mutation assays. Expression of translesion polymerase component Rev7 was identified as a target of SBF-dependent regulation. (C) 2009 Elsevier Inc. All rights reserved.