A mathematical model including convection, axial dispersion, external-and intraparticle mass transfer resistances, particle size distribution (PSD) and variation of isotherm (VOI) was developed for analyzing the adsorption process of solanesol by macroporous resins. The theoretical predictions were compared with the experimental data obtained at different conditions to examine the validity of the model. The results showed that the theoretical predictions were very consistent with the experimental data. The model parameters were investigated using the model developed. The results showed that: (a) As Pe, Bi, m, n, and a increased and b decreased, the time required to reach the breakthrough point was delayed and the loading capacity at the breakthrough point was increased; (b) When Pe is greater than 50, the effect of axial diffusion decreased to a negligible level, and (c) At the region of low values of m and n, the breakthrough curves changed severely and the adsorption column was penetrated through easily.