Simulated Moving Bed (SMB) technology has played an important role in the separation of binary mixtures. An exact adjustment of the volumetric flow rates is necessary for trouble-free operation. In this contribution, an adaptive control concept is introduced that determines the necessary control variables for complete automatic separation. A simple model is derived for the movement of the concentration fronts and a controller is developed based oil the model. The simulation result shows the potential of applying such a control design for application in industrial use.