In this work, the potential for the auto-ignition of Iranian heavy oil during in situ combustion (ISC) process conditions was studied. Kinetic studies were carried out using thermal analysis techniques. Effects of oxygen partial pressure, reservoir pressure, and clay on the auto-ignition condition were investigated. Based on the experimental results obtained, a kinetic equation was derived for each of the different oil samples in the presence of different sands. The effect of partial pressure of oxygen in the injected air showed that at atmospheric pressure, low temperature combustion (LTC) was initiated at 275C. Also, enriching the injected air by oxygen lowers the initial LTC temperature by up to 50C. ARC experiments were undertaken to extend the studies to reservoir pressure conditions (1300psi). It was found that activation energy in the LTC region was lowered as a consequence. As a result, initiation of LTC commenced at 115C when air was injected. The effect of clay as a catalyst was also studied, and it was found that the activation energy decreases considerably when clay is present in the system. Experiments in a high-pressure combustion tube showed that LTC was initiated in the temperature range 120-150C, which is in line with the results obtained in the ARC. Fire flooding was sustained during the combustion tube test.