In the absence of H2S and with the addition of inlet H2S content 719 ppm for 4 hours, 8 hours and 12 hours respectively, the global reaction rates of methanol decomposition were determined over phi 5x5 mm cylindrical pellet of C207 Cu-based catalyst at atmospheric pressure in an internal recycle gradientless reactor. The pore size distribution, the profile of sulfur in pellet, and the tortuosity factor of the poisoned catalyst were also measured. The hydrogen sulfide poisoning of commercial catalyst was considered as the shell-progressive poisoning. The experimental values of the non-poisoned dimensionless radius x(C) by Auger Electron Spectroscopy were 0.938, 0.916 and 0.896 respectively with the addition of H2S for 4 hours, 8 hours and 12 hours, which were in agreement with the values calculated by the intrinsic deactivation kinetics.