The stability of protonated and ionized hydroxylamine in relation to their reactivity with molecular hydrogen has been studied. All stationary points and transition states for the reactions of H-2 with protonated and ionized hydroxylamine have been determined at the MP2(full) level with the cc-pVTZ basis set. Energetic data have been obtained at the CCSD(T) level employing the aug-cc-pVTZ basis set. The analysis of the potential energy surfaces corresponding to both reactions shows that molecular H-2 cannot react either with protonated or ionized hydroxylamine under interstellar conditions. Therefore both ionized and protonated hydroxylamine may participate in synthetic routes of amino acids. (C) 2009 Elsevier B. V. All rights reserved.