Chemistry Letters, Vol.37, No.11, 1172-1173, 2008
Accurate Measurement of Vicinal Carbon-Hydrogen Coupling Constants via Ammonium Nitrogen Based on HMBC Experiments
Vicinal spin-spin Coupling constants frequently used for conformation analysis were determined for ammonium-containing C-13-N-C-H-1 systems by using HMBC. 1-Deoxynojirimycin hydrochloride provided an appropriate system for measuring the antiperiplanar and gauche interactions, which were determined to be 7.3 and 1.6 Hz, respectively.