Chemistry Letters, Vol.38, No.2, 114-115, 2009
Synthesis of 25-C-13-Amphotericin B Methyl Ester: A Molecular Probe for Solid-state NMR Measurements
A C-13-labeled amphotericin B (AmB) derivative was synthesized based on a hybrid strategy combining chemical synthesis with degradation of a natural product through Successive cross-coupling reactions and macrolactonization. The specimen regiospecifically C-13-labeled (99% enrichment) at C25 position corresponding to the polyene moiety would be a powerful tool for structural analysis of the molecular assembly formed by AmB based on solid-state NMR measurements.