Chemistry Letters, Vol.38, No.4, 328-329, 2009
Synthesis of Oxindoles by Palladium-catalyzed C-H Bond Amidation
Treatment of N-tosylphenylacetamide derivatives with copper(II) acetate in the presence of a catalytic amount of palladium(II) acetate affords 3,3-disubstituted oxindoles. The reaction proceeds through the intramolecular metallation of an aromatic C-H bond and the following C-N bond formation by reductive elimination.