Chemistry Letters, Vol.38, No.7, 684-685, 2009
Phosphatidylserine-selective Conformational Change of alpha-Helix Peptide, Td3717, and Its Ability to Transfect Cancer Cells
A synthetic peptide, Td3717, showed selective affinity for anionic phospholipids, phosphatidylserine and phosphatidylglycerol, and formed an amphiphilic alpha-helical structure. This specificity originated not only from electrostatic interactions, but also from the primary amino acid sequence and overall structure of the peptide.