Chemistry Letters, Vol.38, No.7, 718-719, 2009
Intracellular Enzyme-responsive Fragmentation of Nonviral Gene Carriers Leads to Polyplex Destabilization and Enhanced Transgene Expression
A novel cationic oligopeptide has been developed for bio-processing-triggered nonviral gene delivery systems. Intracellular fragmentation of the carrier in response to endogenous enzyme, furin, led to destabilized polyplexes and enhanced transgene expression.