화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.17, No.12, 969-975, December, 2009
Export Citation
Topical Delivery of Budesonide Emulsion Particles in the Presence of PEO-PCL-PEO Triblock Copolymers
Jin Hun Cho, Hyon Ho Baek, Jung Min Lee, Jung Hyun Kim†, Dae Duk Kim1, Heui Kyoung Cho2, and In Woo Cheong2, †
  • Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, Korea
  • 1College of Pharmacy, Seoul National University, Seoul 151-742, Korea
  • 2Department of Applied Chemistry, Kyungpook National University, Daegu 702-701, Korea
E-mail:,
This article describes the topical delivery and localization of budesonide through the hairless mouse skin. Two poly(ethylene oxide)-block-poly(ε-caprolactone)-block-poly(ethylene oxide) (PEO-PCL-PEO) triblock copolymers (T 222 and T 252) having different CL:EO ratios were added in the preparation of budesonide particles stabilized with poly(vinyl alcohol) (PVA) and Tween 80 under ultrasonication. For comparison, a commercial PEO-PPOPEO triblock copolymer (F68) was studied under the same condition. To demonstrate the effects of the triblock copolymer, the particle size of budesonide emulsion, entrapment efficiency, and in vitro release were measured and compared. The budesonide particles stabilized by the triblock copolymers had a diameter of ca. 350 nm with entrapment efficiencies of 66-76%. The In vitro release profiles of all samples showed an initial burst followed by sustained release. The skin penetration and permeation of budesonide were analyzed by using a Frantz diffusion cell. T 222 and T 252 exhibited higher total permeation amounts, but lower budesonide penetration amounts, than F68. The results suggest that the partitioning of budesonide in each skin layer can be adjusted in order to avoid skin thinning and negative immune response arising from the penetration of budesonide in blood vessels.
Keywords:topical delivery;budesonide;triblock copolymers;permeation;penetration
  1. Zhou S, Deng X, Yang H, Biomaterials, 24, 3563 (2003)
  2. Dong Y, Feng SS, Biomaterials, 25, 2843 (2004)
  3. Mukerjee A, Sinha VR, Pruthi V, J. Biomed. & Pharma. Eng., 1, 40 (2007)
  4. Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE, J. Control. Release, 70, 1 (2001)
  5. Kim SY, Cho SH, Lee YM, Chu LY, Macromol. Res., 15(7), 646 (2007)
  6. Lee CM, Jeong HJ, Park JW, Kim J, Lee KY, Macromol. Res., 16(8), 682 (2008)
  7. Lee JY, Cho EC, Cho KW, J. Control. Release, 94, 323 (2004)
  8. Letchford K, Burt H, Eur. J. Pharm. Biopharm., 65, 259 (2007)
  9. Kim J, Choi SY, Kim KM, Go DH, Jeon HJ, Lee JY, Park HS, Lee CH, Park HM, Macromol. Res., 15(4), 337 (2007)
  10. Xiong XY, Tam KC, Gan LH, Macromolecules, 36(26), 9979 (2003)
  11. Lee JW, Hua FJ, Lee DS, J. Control. Release, 73, 315 (2001)
  12. Hwang MJ, Suh JM, Bae YH, Kim SW, Jeong B, Biomacromolecules, 6(2), 885 (2005)
  13. Gong CY, Qian ZY, Liu CB, Huang MJ, Gu YC, Wen YJ, Kan B, Wang K, Dai M, Li XY, Gou ML, Tu MJ, Wei YQ, Smart Mater. Struct., 16, 927 (2007)
  14. Zhang Y, Zhuo RX, Biomaterials, 26, 6736 (2005)
  15. Cho HK, Cho JH, Cheong IW, Micromol. Symp., 96 (2007)
  16. Kim DH, Ko YS, Kwon YK, Macromol. Res., 16(1), 62 (2008)
  17. Szefler SJ, J. Allergy Clin. Immun., 104, S175 (1999)
  18. Kis K, Bodai L, Polyanka H, Eder K, Pivarcsi A, Duda E, Soos G, Bata-Csorgo Z, Kemeny L, Inter. Immunopharmacology, 6, 358 (2006)
  19. Schacke H, Docke WD, Asadullah K, Pharmacol. Therapeut., 96, 23 (2002)
  20. Park JS, Cho YW, Macromol. Res., 15(6), 513 (2007)
  21. Shim JW, Kang HS, Park WS, Han SH, Kim JO, Chang IS, J. Control. Release, 97, 477 (2004)
  22. Monika SK, Wolfgang M, Korting HC, Adv. Drug Deliver. Rev., 59, 427 (2007)
  23. Cho HK, Cho KS, Cho JH, Choi SW, Kim JH, Jung IW, Colloid Surface B, 65, 61 (2008)
  24. Cho G, Glatzhofer DT, J. Ind. Eng. Chem., 3(1), 29 (1997)
  25. Cho HK, Lone S, Kim DD, Choi JH, Choi SW, Cho JH, Kim JH, Cheong IW, Polymer, 50, 2357 (2009)
  26. Verma DD, Verma S, Blume G, Fahr A, Inter. J. Pharm., 258, 141 (2003)
  27. Boris YS, Partibhash C, Henry HY, Albert HL, Pharmaceut. Res., 24, 203 (2007)
  28. Alvarez-Roman R, Naik A, Kalia YN, Guy RH, Fessi H, J. Control. Release, 99, 53 (2004)