화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of the Korean Industrial and Engineering Chemistry, Vol.20, No.6, 581-585, December, 2009
Export Citation
포도당 응답성 약물전달시스템의 연구 동향
Trends in the Studies of Glucose-Responsive Drug Delivery Systems
조성민, 김진철†
  • 강원대학교 생물소재공학전공 유효성분전달소재연구실
Seong-Min Jo, and Jin-Chul Kim†
  • Department of Biomaterials Engineering, Kangwon National University, Kangwon-do 201-701, Korea
E-mail:
초록
당뇨병은 인슐린 분비가 부족하거나 그 인식 기능이 감소하여 발생하는 만성질환으로, 현재까지도 완전한 치료법은 개발되지 못하고 있다. 그 중 제I형 당뇨병에 가장 많이 쓰이는 치료법은 인슐린 주사로 알려져 있다. 하지만 인슐린 주사는 때로 치명적인 위험과 불편함을 수반하므로, 이를 개선하기 위한 많은 연구들이 수행되고 있다. 이러한 방법의 일환으로, 자가 조절 인슐린 전달 시스템이 제안되었다. 본 총설에서는 현재까지 연구되고 있는 대표적인 자가 조절 인슐린 전달 시스템의 포도당 응답성 방출 원리에 대해 살펴보고자 한다.
Diabetes is caused by the lack of insulin secretion or the reduction in its sensitivity. The recent treatments for diabetes do not fulfill the requirements for the maintaining of normal blood glucose level. The most frequently used treatment for type I diabetes is an insulin injection. However, the insulin injection often involves the life-threatening risk and the low compliance of patients. Accordingly, extensive studies have been done to overcome the shortcomings of the injection. A representative approach is to employ self-regulated insulin delivery systems. This report includes the principles of glucose-responsive release in the self-regulated insulin delivery systems.
Keywords:self-regulated insulin delivery;glucose-responsive release;concanavalin A;glucose oxidase;phenylboronic acid
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