Based on experimental data, a simulation and optimisation of the adsorption-microfiltration (AMF) process for boron removal from reverse osmosis (RO) permeate was done. An impressively low flow rate of the dry boron adsorbent of about only 54.3 kg h(-1) is needed in the adsorbent recirculation loop of a unit for treatment of 100 m(3) h(-1) of RO permeate and boron concentration in the feed and raffinate 1.2 and 0.4 mg dm(-3), respectively. The optimum concentrations of dry adsorbent in the suspension leaving submerged microfiltration module (MF1) and cross-flow microfilters are 110 and 200 kg m(-3), respectively. A diafiltration of regenerated adsorbent suspension is an effective way of decreasing of adsorbent flow rate and consumption of chemicals in the desorption loop. Use of about 0.5% of the raffinate for diafiltration is optimal. Specific consumption of regeneration media per unit volume of raffinate at these conditions are 0.97 and 0.19 mol m(-3) for acid and alkali, respectively. Segmentation of submerged MF1 module is a useful way of reducing membrane area needed, which is at an optimal conditions in case of ideal mixing in segmented and non-segmented MF1 modules 1315 and 1695 m(2), respectively. The overall theoretical power input for MF pumps and air blower is of about 0.018 kWh m(-3).