Pt nanoparticles supported on niobium (Nb)-doped titania (TiO2) were prepared using the alcohol reduction method. The 10 mol % Nb-doped TiO2 (10Nb-TiO2) was subjected to various heat-treatments. Depending on the heat-treatment either anatase or rutile 10Nb-TiO2 was produced. The change in Pt morphology when deposited on 10Nb-TiO2 supports that were treated under hydrogen at different temperatures was investigated by high-resolution transmission electron microscopy. Platinum particles deposited on rutile 10Nb-TiO2 and anatase 10Nb-TiO2 have distinctly different morphologies. Those deposited on anatase 10Nb-TiO2 are similar to Pt/C and are essentially spherical. Platinum particles on rutile 10Nb-TiO2, however, appear flattened, indicating a strong metal-support interaction.