This paper presents the detailed laboratory experimental results of a low-temperature Organic Rankine Cycle (ORC) engine coupled with a Reverse Osmosis (RO) desalination unit. In a previous work, the identification of performance of the scroll type expander was presented. At that primary experimental phase an electric brake was co-axially connected to the expander to act as the mechanical load of the ORC engine. The identification of behaviour of the integrated ORC-RO system is a research step ahead since the electric brake is replaced by the RO desalination unit representing the actual system's mechanical load. Several characteristic quantities of both energy supply (ORC) and demand (RO) side have been measured and are illustrated in the current paper. The results show that ORC can be effectively used to exploit low-temperature thermal sources (i.e. in the range from 40 to 70 degrees C) for desalination of sea or brackish water through the RO process. Such low-temperature values can be available from excess industrial heat, solar collectors and geothermal fields making the ORC-RO process an alternative desalination variant. However, it becomes clear that the system performance strongly depends on the corresponding operation point. (C) 2009 Elsevier Ltd. All rights reserved.