In this study, simulation of a variable air volume (VAV) air conditioning system in an existing office building is presented for the cooling mode. A building simulation package was used for the simulation [DOE, EnergyPlus Engineering Document, Version 1.3., U.S. Department of Energy, Washington, DC, 2005]. The design information of the existing office building, the actual number of the internal load sources such as occupants, lighting, office equipments and the manufacturer's data for the existing rooftop unit (RTU) and the VAV boxes were used in the building simulation package. The simulation results; RTU power consumption, indoor zone temperature and relative humidity, were validated with the data obtained from the on-site measurements performed in the existing office building under the same outdoor conditions. It was found that 71.1% of all simulated power consumption data falls within 15% range from the experimental data. The reason for the existence of some data out of band is due to the possible errors associated with the difference in the solar data used for the location 40 km away from the experimental location. It was found that 90.6-94.7% of the indoor temperature experimental data fall within +/- 1.5 degrees C range from the simulated data. and 88.3-91.3% of the indoor relative humidity data fall within +/- 18% range from the simulated data. (C) 2009 Elsevier B.V. All rights reserved.