This paper presents a strategy for improving the reliability and the energy efficiency of chiller sequencing control based on the total cooling load measurement of centralized multiple centrifugal chiller plants. The improvement is achieved as follows. Firstly, a fused measurement of building cooling load is used to replace the direct/indirect measurement. Secondly, the maximum cooling capacity of individual chillers is computed online using a simplified centrifugal chiller model. Thirdly, the online computed maximum cooling capacity is calibrated according to the quality of the fused measurement in order to deal with the possible misbehaviours in measurement instruments. A simplified model for computing the maximum cooling capacity is developed and validated using field data. The performance of the proposed chiller sequencing control strategy is tested and compared with a conventional chiller sequencing control algorithm. Test results are presented showing that the proposed strategy can effectively improve the reliability of chiller sequencing control and reduce the energy consumption of chiller plants. (C) 2009 Elsevier B.V. All rights reserved.