R22, the HCFC most widely used in refrigeration and air-conditioning systems in the last years, is phasing-out. R422D, a zero ozone-depleting mixture of R125, R134a and R600a (65.1%/31.5%/3.4% by weight, respectively), has been recently proposed as a drop-in substitute. For energy consumption calculations and temperature control, it is of primary importance to estimate operating conditions after substitution. To determine pressure drop in the evaporator and piping line to the compressor, in this paper the experimental adiabatic pressure gradients during flow boiling of R422D are reported for a circular smooth horizontal tube (3.00 mm inner radius) in a range of operating conditions of interest for dry-expansion evaporators. The data are used to establish the best predictive method for calculations and its accuracy: the Moreno-Quiben and Thome method provided the best predictions for the whole database and also for the segregated data in the annular flow regime. Finally, the experimental data have been compared with the adiabatic pressure gradients of both R22 and its much used alternative R407C available in the literature. (C) 2009 Elsevier Ltd. All rights reserved.