Preparation of poly(vinyl alcohol)/poly(acrylic acid) microcapsules and microspheres and their pH-responsive release behavior

Jumi Yun; Hyung-Il Kim

Journal of Industrial and Engineering Chemistry, Vol.15, No.6, 902-906, November, 2009

DOI10.1016/j.jiec.2009.09.021 Export Citation

Preparation of poly(vinyl alcohol)/poly(acrylic acid) microcapsules and microspheres and their pH-responsive release behavior

Jumi Yun, and Hyung-Il Kim^†

Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University, Daejeon 305-764, Republic of Korea

E-mail:

The pH-responsive poly(vinyl alcohol)/poly(acrylic acid) hydrogel microparticles containing vitamin B12 were prepared with emulsion polymerization. Bothmicrocapsule andmicrosphere were easily produced by simply changing the sequence of ingredient addition during the emulsion polymerization. The microparticles showed the faster and larger release of vitamin B12 due to the higher swelling of hydrogel by electrostatic repulsion of carboxylate groups in poly(acrylic acid) as the pH was changed into more basic condition. The microcapsules showed a faster release than the microspheres did due to the less hindered passage through the thinner shell of microcapsules. The poly(vinyl alcohol)/poly(acrylic acid) hydrogel microparticles either protected or released the vitamin B12 effectively depending on pH.

Keywords:Hydrogel;pH-responsive release;Microcapsules;Microspheres

[References]

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Huang HY, Remsen EE, Kowalewski T, Wooley KL, J. Am. Chem. Soc., 121(15), 3805 (1999)
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Landfester K, Adv. Mater., 13(10), 765 (2001)
Peppas NA, Wright SL, Eur. J. Pharm. Biopharm., 46, 15 (1998)
Kim JH, Lee SB, Kim SJ, Lee YM, Polymer, 43(26), 7549 (2002)

[Referenced By]

[Related Articles]

[1] Langer R, Nature, 392(6679), 5 (1998)

[2] Lin G, Chang S, Kuo CH, Magda J, Solzbacher F, Sens. Actuators. B-Chem., 136, 186 (2009)

[3] Janovak L, Varga J, Kemeny L, Dekany I, Appl. Clay Sci., 43, 260 (2009)

[4] Hamidi M, Azadi A, Rafiei P, Adv. Drug Del. Rev., 60, 1638 (2008)

[5] Hoare TR, Kohane DS, Polymer, 49(8), 1993 (2008)

[6] Sherwood L, Human Physiology from Cells to Systems, third edn, Wadsworth Publishing Company, California, 1997.

[7] Martin GR, Jain RK, Cancer Res., 54, 5670 (1994)

[8] Qiu Y, Park K, Adv. Drug Del. Rev., 53, 321 (2001)

[9] Sinha VR, Trehan A, J. Control. Release, 90, 261 (2003)

[10] Zhou S, Liao X, Li X, Deng X, Li H, J. Control. Release, 86, 195 (2003)

[11] Hamman JH, Enslin GM, Kotze AF, Biodrugs, 19, 165 (2005)

[12] Pimentel-Gonzalez DJ, Campos-Montiel RG, Lobato-Calleros C, Pedroza-Islas R, Vernon-Carter EJ, Food Res. Int., 42, 292 (2009)

[13] Yuan W, Wu F, Guo M, Jin T, Eur. J. Pharm. Sci., 36, 212 (2009)

[14] Schoubben A, Blasi P, Giovagnoli S, Perioli L, Rossi C, Ricci M, Eur. J. Pharm. Sci., 36, 226 (2009)

[15] Huang HY, Remsen EE, Kowalewski T, Wooley KL, J. Am. Chem. Soc., 121(15), 3805 (1999)

[16] Emmerich O, Hugenberg N, Schmidt M, Sheiko SS, Baumann F, Deubzer B, Weis J, Ebenhoch J, Adv. Mater., 11(15), 1299 (1999)

[17] Landfester K, Adv. Mater., 13(10), 765 (2001)

[18] Peppas NA, Wright SL, Eur. J. Pharm. Biopharm., 46, 15 (1998)

[19] Kim JH, Lee SB, Kim SJ, Lee YM, Polymer, 43(26), 7549 (2002)