A polymerizable hindered amine-based antimicrobial fibrous material was successfully prepared by grafting 2,2,6,6-tetramethyl-4-piperdyl rnethacrylate onto cotton fabrics and sequentially chlorinating the grafted materials with diluted sodium hypochlorite solutions. The effects of grafting conditions on the grafting reactions were investigated. The resultant polymeric amine N-halamine fibrous material provided a total kill of 10 107 cfu/mL of Escherichia coli (ATCC 15597), Staphylococcus epidermidis (ATCC 35984), and Staphylococcus aureus (ATCC 6538) within 30 min. Autoclave treatment and TGA study showed that the covalently bound chlorines have excellent thermal and hydrolytic stabilities. The antimicrobial function was both durable and rechargeable. These properties make the new fibrous materials attractive candidates for a broad range of applications.