Reactive distillation (RD), a proven reactive separation method that can enhance yields and improve product selectivity in multiple reactant/product systems, was shown to be feasible for FTS in our earlier papers using a simplified kinetics [Srinivas et al. Feasibility of Reactive Distillation for Fischer-Tropsch Synthesis. Ind. Eng. Chem. Res. 2008, 48, 889-899; DOI 10.1021/ie071094p] as well as a detailed kinetics [Srinivas et al. Feasibility of Reactive Distillation for Fischer-Tropsch Synthesis. 2. Ind. Eng. Chem. Res. 2009; DOI 10.1021/ie801887m]. In-built thermodynamic procedures of Aspen Plus, along with a detailed kinetic model that predicts product distribution, were used in performing the simulations. In this paper, we present detailed parametric studies like effect of reflux ratio, H-2/CO feed ratio, number of nonreactive stages, etc. Conversion, yield, olefin-to-paraffin ratio and product distribution are the parameters used for comparison among the different cases studied. Within RD mode for FTS, some of the alternate column configurations like those with a side-heat removal and a side-draw, a hybrid column with reactive and nonreactive stages, are also explored and investigated.