The NO reduction over CuO/gamma-Al2O3 catalyst in a bubbling fluidized bed reactor has been determined on the basis of the two-phase model at the maximum conversion temperature of 300 degrees C. This temperature is critical as it deals maximum conversion, NH3 adsorption/desorption, and NH3 oxidation, which also takes place above this temperature and hence causes a decrease of NO reduction. The effects of superficial gas velocity (u(g)), [NH3]/[NO] molar ratio, and the static bed height (h(s)) on the reduction efficiency of NO over CuO/gamma-Al2O3 as a bed material in a fluidized bed reactor with variation of reaction temperatures (rate constant, k(r)) have been determined, and a model has been developed for the NO removal process in a bubbling fluidized bed using the two-phase theory. The results are compared with the Simulation results obtained through the Maple and MATLAB simulation tools.