Granulation is one of the fundamental operations in particulate processing; however, there is still need to provide insight into the complex dynamic state behavior of these units. The unsteady state of all industrial multichamber fluidized-bed granulator for Urea production, with variable mass holdup, is studied under different imposed step changes in key operating variables. For the assayed disturbances, the unit dynamics is considerably slow. In fact, many important state variables (e.g., bed height, pressure drop, solid mass flow, etc.) required more than 1 h to achieve the new steady state. The observed nonsteady behavior indicates the need of all efficient control to return the system rapidly to the desired operational point. The discharge area, fluidization air flow rate, and temperature were determined to be the more appropriate manipulative variables, for granulator stability control purposes.