This article presents an original motion control strategy for robot manipulators based on the coupling of the inverse dynamics method with the so-called second-order sliding mode control approach. Using this method, in principle, all the coupling non-linearities in the dynamical model of the manipulator are compensated, transforming the multi-input non-linear system into a linear and decoupled one. Actually, since the inverse dynamics relies on an identified model, some residual uncertain terms remain and perturb the linear and decoupled system. This motivates the use of a robust control design approach to complete the control scheme. In this article the sliding mode control methodology is adopted. Sliding mode control has many appreciable features, such as design simplicity and robustness versus a wide class of uncertainties and disturbances. Yet conventional sliding mode control seems inappropriate to be applied in robotics since it can generate the so-called chattering effect, which can be destructive for the controlled robot. In this article, this problem is suitably circumvented by designing a second-order sliding mode controller capable of generating a continuous control law making the proposed sliding mode controller actually applicable to industrial robots. To build the inverse dynamics part of the proposed controller, a suitable dynamical model of the system has been formulated, and its parameters have been accurately identified relying on a practical MIMO identification procedure recently devised. The proposed inverse dynamics-based second-order sliding mode controller has been experimentally tested on a COMAU SMART3-S2 industrial manipulator, demonstrating the tracking properties and the good performances of the controlled system.