In this article, the identification of a class of multiscale spatio-temporal dynamical systems, which incorporate multiple spatial scales, from observations is studied. The proposed approach is a combination of Adams integration and an orthogonal least squares algorithm, in which the multiscale operators are expanded, using polynomials as basis functions, and the spatial derivatives are estimated by finite difference methods. The coefficients of the polynomials can vary with respect to the space domain to represent the feature of multiple scales involved in the system dynamics and are approximated using a B-spline wavelet multi-resolution analysis. The resulting identified models of the spatio-temporal evolution form a system of partial differential equations with different spatial scales. Examples are provided to demonstrate the efficiency of the proposed method.