The influences of nano-particles (nano-sized CaCO3 and nano-sized SiO2) on plasticizers volatility, solvent extraction stability, and exudation stability of flexible PVC were studied. The results showed that nano-particles could reduce migration of plasticizers, thus improved the ability of anti-migration of flexible PVC. Further more, nano-sized SiO2 shows excellent property than nano-sized CaCO3 in resistance migration of plasticizers. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 115: 2178-2182, 2010