Journal of Bioscience and Bioengineering, Vol.108, No.3, 244-247, 2009
Human beta defensin-3 engineered keratinocyte sheets constructed by a magnetic force-based tissue engineering technique
A multilayered keratinocyte sheet overexpressing human beta defensin-3 (HBD-3) gene was prepared by the magnetic force-based tissue engineering technique. The cell sheet demonstrated significant antimicrobial activity, indicating that the therapeutic introduction of HBD-3 gene into cell sheets may provide a new gene therapy strategy for infectious diseases. (C) 2009, The Society for Biotechnology, Japan. All rights reserved.