In the first of this two-paper series, a new model was developed for calculating the electric potential field in a long, thin nanochannel with overlapped electric double layers. The model takes into account the dependence of ion mobility on local ion densities and pH. This model is used here to Study and demonstrate the effect of ion density and pH on ionic current measurements. A comparison is shown of predictions based on each of three boundary conditions, as studied in Part I. The model developed in Part I is validated by comparing simulations with measurements of ionic current as a function of sodium borate concentration. Results show that predictions based on extended Debye-Huckel theory for ion mobility significantly improve the accuracy of simulations, but that these do not predict exact scaling behavior. A simple bulk conductivity measurement used as input parameter for the Simulations, in place of the predicted bulk conductivity (KO), guarantees agreement with data in the thin EDL region. Results also indicate that the charge regulation boundary condition, complemented with an adequate bulk electrolyte model, provides better agreement with experimental trends than the specified zeta potential or specified surface net charge boundary conditions. Further, it is Shown that Currents due to advection (by electroosmotic flow) are in all cases studied less than 25% of the total Current in the system. (C) 2008 Elsevier Inc. All rights reserved.