We report preparation of highly photoluminescent CdSe@ZnS quantum dot-polystyrene composite beads, by employing stepwisely: (1) a simultaneous ZnS shell formation and ligand exchange with 3-mercaptopropyltrimethoxy silane ( MPS); (2) coupling MPS with polymerizable 3-(trimethoxysily) propylmethacrylate (MPM); and (3) polymerization of the resulting MPM-MPS capped CdSe@ZnS quantum dots with styrene molecules. The functionalized quantum dots exhibited robust chemical stability against the harsh radical polymerization condition and the resulting polymer microbeads were strong against photobleaching under an intense and continuous laser.