Vacuum-enhanced direct contact membrane distillation (VEDCMD) and forward osmosis (FO) were investigated for water recovery enhancement in desalination of brackish water. Past studies have demonstrated that both VEDCMD and FO can be effectively utilized in the treatment of a wide range of highly concentrated feed solutions. In the current study, two reverse osmosis (RO) brine streams with total dissolved solids concentrations averaging 7500 and 17,500 mg/L were further desalinated by VEDCMD and by FO. in both processes, high water recoveries were achieved; however, recoveries were limited by precipitation of inorganic salts on the membrane surface. Various cleaning techniques were able to remove the scale layer from the membrane and restore water flux to almost initial levels. FO achieved water recoveries Up to 90% from the brines and VEDCMD achieved water recoveries up to 81% from the brines. Addition of a scale inhibitor during both processes was effective at maintaining high water flux for extended time. When considering the total water recovery (the recovery from the RO processes combined with the batch recovery from the VEDCMD or FO process), greater than 96 and 98% total recoveries were achieved for the two different brine streams. (C) 2009 Elsevier B.V. At I rights reserved.