We present molecular dynamics simulations of interfaces relevant to the selective chemical extraction of: uranyl ions from aqueous solution. These molecular-level simulations model ion transfer in the PUREX process and in synthetic, selective membranes. We first present simulations of water/oil interfaces modified by incorporation of tributyl phosphate (TBP) into the oil phase (hexane). A range of concentrations is examined, from a single TBP molecule to values close to those utilized in the PUREX process. The TBP molecules exhibit strong interfacial activity, and the interface broadens relative to the water/oil case with increasing TBP concentrations. Additional structural features, including radial distribution functions and orientational distributions, are examined to elucidate the molecular ordering at the interface; the interface structure changes substantially with increasing TBP concentration. Finally, free-energy profiles are computed for (1) a single TBP molecule and a single uranyl nitrate complex [UO2(NO3)(2)] across the water/oil interface and (2) a UO2(NO3)(2)center dot TBP2 complex across both water/oil and water/(oil+TBP) interfaces. The UO2(NO3)(2) complex is strongly repelled from the water/oil interface, while the UO2(NO3)(2)center dot TBP2 complex exhibits interfacial activity that decreases with increasing TBP concentration. The UO2(NO3)(2)center dot TBP2 complex displays a net free-energy driving force for partitioning into the oil phase that increases with increasing TBP concentration.