A polyHIPE is a highly Porous, emulsion-templated polymer synthesized by polymerizing a monomer and a crosslinking comonomer in the continuous phase of a high-internal phase emulsion (HIPE) The synthesis of degradable polyHIPE could be of interest for biomedical applications such as tissue engineering scaffolds. In this research, a poly(epsilon-caprolactone) (PCL) oligomer with terminal vinyl groups was used as the crosslinking comonomer For a polyHIPE based on t-butyl acrylate (tBA) The porous structure, properties, water absorption, and hydrolytic degradation of the polyHIPE were investigated. The polyHIPE containing 50 wt % PCL exhibited very large voids, 1 to 3 mm in diameter that resulted from the destabilization of the HIPE on addition of PCL, making the polyHIPE more suitable for tissue engineering applications. The relatively flexible PCL enhanced segmental mobility, yielding two glass transition temperatures and a significant reduction in modulus. When exposed to a 3 M aqueous solution of NaOH, the t-butyl groups underwent hydrolysis and the PCL underwent degradation, rapidly leading to the complete disintegration of the macromolecular structure. The tBA-based polyHIPE containing 50 wt % PCL exhibited enhanced cell adhesion, penetration, and growth indicating that it is a suitable candidate for further research and development (C) 2009 Wiley Periodicals, Inc J Polym Sci Part A. Polym Chem 47 7043-7053, 2009