후코이단의 보습제 및 화장품재료로서 특성

차성한; 이정식; 김영숙; 김동욱; 문재천; 박권필; Sung Hwan Cha; Jung Shik Lee; Young Suk Kim; Donguk Kim; Jae Cheon Moon; Kwonpil Park

Korean Chemical Engineering Research, Vol.48, No.1, 27-32, February, 2010

Export Citation

후코이단의 보습제 및 화장품재료로서 특성

Properties of Fucoidan as Raw Materials of Water-holding Cream and Cosmetics

차성한, 이정식¹, 김영숙¹, 김동욱 ², 문재천³, 박권필 ^†

순천대학교 화학공학과, 540-742 전남 순천시 매곡동 315
¹(주)해림후코이단, 537-801 전남 완도군 완도읍 가용리 1088-8
²인제대학교 제약공학과, 621-749 경남 김해시 어방동 607
³순천제일병원 피부과, 540-968 전남 순천시 조례동 1589-1

Sung Hwan Cha, Jung Shik Lee¹, Young Suk Kim¹, Donguk Kim², Jae Cheon Moon³, and Kwonpil Park^†

Department of Chemical Engineering, Sunchon National University, 315 Maegok-dong, Suncheon, Jeonnam 540-742, Korea
¹Haerim Fucoidan Ltd, 1088-8 Gayong-ri Wando-eup, Wando-gun, Jeonnam 537-801, Korea
²Department of Pharmaceutical Engineering, Inje University, 607 Obang-dong, Gimhae, Gyongnam 621-749, Korea
³Department of Dermatology, Suncheon Jeil Hospital, 1589-1 Jorye-dong, Suncheon, Jeonnam 540-968, Korea

E-mail:

초록

후코이단을 보습제 및 기능성화장품 소재로 사용하기 위한 후코이단 특성 및 그 효과에 대해 연구하였다. 후코이단은 미역 포자엽에서 추출하였다. 화장품 소재 시험으로는 보습력 측정, 항산화(DPPH assay, radical scavenging), 안전성(MTT assay)을 실시하였다. 후코이단의 보습력은 최고의 보습제 중의 하나인 히아루론산의 보습력보다 높았고, 분자량이 감소함에 따라 보습력이 약간 증가하였다. 후코이단은 높은 안전성과 항산화력을 보였다. 후코이단의 보습력 및 항알레르기 효과를 평가하기 위해 아토피 환자 46명에게 후코이단 크림을 6주간 적용하였다. 증상 정도를 나타내는 IGA 값이 3.04에서 2.15로 감소해 39.8%의 증상개선 효과가 있었다.

Properties of fucoidan used for functional cosmetics agents were studied. Fucoidan was extracted from Undaria pinnatifida sporophylls. To test possibility of fucoidan as a cosmetics material, water-holding property measurement, DPPH free radical scavenging assay and MTT assay were done. Water-holding property of fucoidan was higher than that of hyaruronic acid, which is known as the one of the best water-holding material. The water-holding strength of fucoidan slightly increase as molecular weight of fucoidan decrease. Fucoidan showed high stability from MTT assay and good anti-oxidation property from DPPH assay. To evaluate the effect of water-holding property and anti-alergy property of fucoidan on the atopic dermatitis(AD), 46 AD patients were treated with fucoidan cream. After 6 weeks treatment, Investigation Global Assessment(IGA) scores decreased from 3.04 to 2.15, that is fucoidan cream had a 39.8% benefit effect on atopic dermatitis.

Keywords:Fucoidan;Water-Holding Property;Anti-Oxidation;Cosmetics;Atopic Dermatitis

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Regis D, Olivier B, Jacqueline J, Nicole G, Carbohydr. Res., 322, 291 (1999)
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Dodgson KS, Biochem. J., 78, 312 (1961)
Kim T, Lee J, Cho G, Park K, Korean Chem. Eng. Res., 44(6), 597 (2006)
Cho YS, Jung WK, Kim JA, Choi IW, Kim SK, Food Chemistry, 116, 990 (2009)

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[2] Fortun A, Khalil A, Gagne D, Douziech N, Kuntz C, Dupuis G, Atherosclerosis, 156, 11 (2001)

[3] Collis S, Fisher AM, Thtombosis Res., 64, 143 (1991)

[4] Mauray S, Raucourt E, Talbot J, Jozefowicz M, Fischer A, Biochimica et Biophysica Acta-Protein Structure and Molecular Enzymology, 1387, 184 (1998)

[5] Saito A, Yoneda M, Yokohama S, Okada M, Haneda M, Nakamura K, Hepatol. Res., 35, 190 (2006)

[6] Oomizu S, Yanase Y, Suzuki H, Kameyoshi Y, Hide M, Biochem. Biophys. Res. Commun., 350(3), 501 (2006)

[7] Alain N, Frederic C, Catherine BV, Patrick D, Jacquline J, Carbohydr. Res., 289, 201 (1996)

[8] Lionel C, Alain F, Frederic C, Nelly K, Corinne S, Anne-Marie F, Catherine B, Carbohydr. Res., 319, 154 (1999)

[9] Regis D, Olivier B, Jacqueline J, Nicole G, Carbohydr. Res., 322, 291 (1999)

[10] Maruyama H, Tanaka M, Matsuhisa M, Hashimoto M, Sasahara T, Life Science, 80, 775 (2007)

[11] Li B, Wei XJ, Sun JL, Xu SY, Carbohydr. Res., 341, 1135 (2006)

[12] Tatiana NZ, Natalia MS, Irina VN, Andrey SS, Pavel AL, Ludmila AE, Comparative Biochemistry and Physiology Part C, 126, 209 (2000)

[13] Jun S, Urara WF, Hiroshi M, Yoshiharu M, Mitsuaki K, Masahiro W, J. Health. Sci., 51, 394 (2005)

[14] Wang J, Zhang Q, Zhang Z, Zhang J, Li P, Inter. J. Biol. Macromol., 44, 170 (2009)

[15] Bae JS, Lee JS, Kim YS, Sim WJ, Lee H, Chun JY, Park KP, Korean Chem. Eng. Res., 46(5), 886 (2008)

[16] Dodgson KS, Biochem. J., 78, 312 (1961)

[17] Kim T, Lee J, Cho G, Park K, Korean Chem. Eng. Res., 44(6), 597 (2006)

[18] Cho YS, Jung WK, Kim JA, Choi IW, Kim SK, Food Chemistry, 116, 990 (2009)