Journal of Supercritical Fluids, Vol.50, No.2, 118-120, 2009
Synthesis of chiral amino acid derivatives in supercritical carbon dioxide using Rh-PipPhos catalyst
PipPhos ligand was used in the asymmetric Rh-catalysed hydrogenation of N-acyldehydroamino acid esters in supercritical carbon dioxide with enantioselectivities attained up to 97%. The catalytic performance is affected greatly by temperature and both hydrogen and total pressures. (C) 2009 Elsevier B.V. All rights reserved.