Journal of the American Chemical Society, Vol.130, No.16, 5446-5446, 2008
New chemistry with old-functional groups: On the reaction of isonitriles with carboxylic acids - A route to various amide types
Thermolysis of isonitriles with carboxylic acids provides, in one step, N-formyl imides (see, for example, 8 + 19 -> 21). The resultant N-formyl group can be converted to N-H, NCH2OH, or NCH3. This chemistry allows for a new route for synthesizing beta-N (asparagine)linked glycosyl amino acids.