Journal of the American Chemical Society, Vol.130, No.23, 7220-7220, 2008
A Cu(I)-catalyzed C-H alpha-amination of esters. Direct synthesis of hydantoins
This paper describes a novel intermolecular alpha-amination process of esters using CuCl as catalyst and di-tert-butyldiaziridinone as nitrogen source. A variety of hydantoins can be formed effectively under mild reaction conditions.